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Wolfram Syndrome is a rare, inherited condition primarily characterised by the early onset of diabetes and progressive optic atrophy. Because it affects multiple organ systems, the visual decline is often accompanied by hearing loss and urinary tract issues. Optic atrophy associated with Wolfram Syndrome generally emerges within the first decade of life, making comprehensive, multidisciplinary care essential for affected individuals.
10+
years Experience
years Experience
5000+
Patients treated
Patients treated
100+
Countries served
Countries served
NABH
Guided facility
Guided facility
Causes
Wolfram Syndrome is caused by mutations in the WFS1 gene (or less commonly WFS2), which affects cell function across multiple organ systems including the pancreas, optic nerve, and inner ear.
Symptoms
Optic atrophy is typically the second feature to appear (after diabetes mellitus), usually in the first decade of life, causing gradual vision loss. Hearing loss and diabetes insipidus often develop later.
Diagnosis
Genetic testing for the WFS1 gene confirms the diagnosis. OCT and visual field testing assess the optic nerve component, while endocrinology and audiology evaluations assess the other associated features.
Treatment — Stem Cell Therapy
Stem cell therapy is studied for its potential to help support optic nerve tissue affected by Wolfram Syndrome. It addresses the optic atrophy component only — diabetes and hearing loss require separate, ongoing specialist management.
Meet The Team
Our Eye Specialists
Dr. Pawan
Associate Professor, Vitreo-Retina Surgeon. 10+ Years Experience
Retinal disorders, diabetic retinopathy, and advanced retina procedures. Provides diagnostic evaluation and treatment planning for international patients.
Dr.Pallavee
Senior Consultant Ophthalmologist & Eye Surgeon· 26+ yrs experience
Areas of Focus: Cataract surgery, corneal disorders, refractive procedures, and glaucoma management. Provides comprehensive eye care and surgical expertise for global patients.
Dr. Robin
Consultant Ophthalmologist & Eye Surgeon, MD, DO .16+ Years Experience
Areas of Focus: Cataract surgery, corneal disorders, refractive procedures, and glaucoma management. Provides comprehensive eye care and surgical expertise for global patients.
How Stem Cell Therapy May Help
Mesenchymal Stem Cells (MSCs), typically sourced from bone marrow or umbilical cord tissue, are studied for their potential to support optic nerve tissue health, reduce inflammation, and help preserve remaining visual function. The cells are administered via a minimally invasive procedure — most often through a retrobulbar or intravitreal injection — under the supervision of our ophthalmology and regenerative medicine team. This approach does not restore vision already lost in advanced, complete optic atrophy, but may help support remaining nerve function and quality of life in suitable candidates.
Reviews
What Our Patients Say
Aneeket Kushwah
I came from overseas specifically for treatment. The staff not only assisted me with transport but also made the whole experience hassle-free. The medical service was of the highest standard and I was very secure in Delhi
Aamit Arora
Your family is very thankful to stem cell cure india for being there for us. The doctors were very understanding and the staff made it a point to see that we were comfortable during the treatment.
Frequently Asked Questions
Will this treat the diabetes or hearing loss?
“No. Our evaluation and treatment focus specifically on the optic nerve (optic atrophy) component. Diabetes and hearing loss should continue to be managed by the relevant specialists”
Is genetic confirmation required?
” It’s helpful if available, but our team can still review clinical findings and OCT/visual field results if genetic testing hasn’t been done.”
Can vision loss from Wolfram syndrome be prevented or slowed?
“There’s no proven way to prevent the optic nerve atrophy itself at present. Regular annual eye examinations are recommended so vision changes are tracked early, and low-vision support can be introduced as needed.”
