Costeff syndrome (3-methylglutaconic aciduria type III) is a rare genetic condition caused by OPA3 gene mutations, causing early-onset optic atrophy along with movement difficulties such as chorea and spasticity later in life. Genetic testing and specialized neuro-ophthalmology evaluation are often limited where families live, which is why many look abroad for a confirming opinion.
As an extremely rare metabolic-genetic condition, Costeff syndrome requires specific diagnostic testing (urinary organic acid analysis, OPA3 genetic testing) that isn’t widely available everywhere. Families often want both diagnostic confirmation and an honest picture of what can currently be done for the optic nerve component.

Associate Professor, Vitreo-Retina Surgeon. 10+ Years Experience

Senior Consultant Ophthalmologist & Eye Surgeon· 26+ yrs experience

Consultant Ophthalmologist & Eye Surgeon, MD, DO .16+ Years Experience
There is no cure for Costeff syndrome. Our evaluation focuses on confirming disease stage via OCT and visual field testing, and giving families a clear, current picture of the vision component specifically — the movement-related features (chorea, spasticity) remain under ongoing neurology management and are outside what an eye-focused evaluation can address. Where regenerative approaches are discussed, we are explicit that these remain under investigation and are not an established cure.
Suitability depends on the stage and cause of the condition. Before travelling, our team reviews:

Excellent customer service and straight away got some improvement as my eye points stop hurting when i press them so and still on the healing process. Very experienced doctor and lovely people. Happy with it.

I came from overseas specifically for treatment. The staff not only assisted me with transport but also made the whole experience hassle-free. The medical service was of the highest standard and I was very secure in Delhi.
“No, our evaluation and treatment address the optic nerve/vision component only. Movement-related symptoms should be managed by a neurologist.”
” It’s helpful if available, but not mandatory — our team can review based on clinical history and OCT/visual field findings.”
“At present, India’s visa suspension for Mexico nationals means direct travel is not possible. We recommend starting with a remote report review so you’re ready to proceed as soon as the situation changes.”

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